2024年

1. Takahashi R, Isshiki S, Hakozaki M, Kanno Y, Uesugi S, Koseki T, Shiono Y. Altenuene derivatives produced by an endophyte Alternaria alternata. Nat. Prod. Res. 1-8,2024. https://doi.org/10.1080/14786419.2024.2342557

2. Nishihara M, Hirabuchi A, Teshima T, Uesugi S, Takahashi H. Flower color modification in Torenia fournieri by genetic engineering of betacyanin pigments. BMC Plant Biol. 24:614, 2024.  https://doi.org/10.1186/s12870-024-05284-1

3. Shimizu K, Takahashi R, Zulfikar, Hakozaki M, Kanno Y, Uesugi S, Koseki T, Shiono Y. New yellow pigments related to the pitholides from the Endophyte Sordariomycetes sp. Phytochem. Lett. 65:10-14, 2024. https://doi.org/10.1016/j.phytol.2024.11.008

2023年

1. Yano A, Yuki S, Shiraishi A, Hakozaki M, Kanno Y, Kimura K, Uesugi S. Golden berry leaf extract containing withanolides suppresses TNF-α and IL-17 induced IL-6 expression in HeLa cells. Biosci. Biotechnol. Biochem. 87:972-980, 2023.  https://doi.org/10.1093/bbb/zbad070

2. Yano A, Yuki S, Kanno Y, Shiraishi A, Onuma H, Uesugi S. Dihydroisocoumarins of Hydrangea macrophylla var. thunbergia inhibit binding of the SARS-CoV-2 spike protein to ACE2. Biosci. Biotechnol. Biochem. 87:1045-1055, 2023. https://doi.org/10.1093/bbb/zbad078

3. Fukuhara-Obonai K, Shiraishi A, Kimura K, Yano A. Bidesmosidic and monodesmosidic triterpenoid saponins from the grain of Amaranthus hypochondriacus. Phytochem. Let. 58:30-35, 2023. https://doi.org/10.1016/j.phytol.2023.09.005

4. Nishihara M, Hirabuchi A, Goto F, Nishizaki Y, Uesugi S, Watanabe A, Tasaki K, Washiashi R, Sasaki N. Production of yellow-flowered gentian plants  by genetic engineering of betaxanthin pigments. New Phytologist 240:1177-1188, 2023.  https://doi.org/10.1111/nph.19218

5. Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura K. 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation. Free Radical Research 57:208-222, 2023. https://doi.org/10.1080/10715762.2023.2229005

6. Usukhbayar N, Uesugi S, Kimura K. 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines. Biosci. Biotechnol. Biochem. 87:1336-1344, 2023. https://doi.org/10.1093/bbb/zbad117

7. Kurata A, Takeuchi S, Fujiwara R, Tamura K, Imai T, Yamasaki-Yashiki S, Onuma H, Fukuta Y, Shirasaka N, Uegaki K. Activation of the TLR2 signaling pathway by GAPDH from bacterial strain RD055328. Biosci. Biotechnol. Biochem. 87:907-915, 2023. https://doi.org/10.1093/bbb/zbad059

8. 上杉祥太「キク科山菜に含まれる機能性成分」化学と生物 61:468-476, 2023. https://doi.org/10.1271/kagakutoseibutsu.61.468

9. 上杉祥太「岩手生物工学研究センター」日本生物工学会誌 101:646, 2023. https://doi.org/10.34565/seibutsukogaku.101.12_646

2022年

1. Uesugi S, Hakozaki M, Kanno Y, Shiraishi A, Suzuki M, Kimura K, Shiono Y, Yano A. Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus. Fitoterapia 157:105130, 2022. https://doi.org/10.1016/j.fitote.2022.105130

2. Sofian FF, Kikuchi N, Koseki T, Kanno Y, Uesugi S, Shiono Y. Antioxidant p-terphenyl compound, isolated from edible mushroom, Boletopsis leucomelas. Biosci. Biotechnol. Biochem. 86:300-304, 2022. https://doi.org/10.1093/bbb/zbab224

3. Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y. Bidysoxyphenols A-C, dimeric sesquiterpene phenols from the leaves of Dysoxylum parasiticum (Osbeck) Kosterm. Fitoterapia 158:105157, 2022. https://doi.org/10.1016/j.fitote.2022.105157

4. Ito Y, Suzuki A, Nasukawa H, Miyaki K, Yano A, Nagasawa T. Ameliorative effects of Japanese barnyard millet (Echinochloa esculenta H. Scholz) bran supplementation in streptozotocin-induced diabetic rats. Food Sci. Technol. Res.  28:431-439, 2022.  https://doi.org/10.3136/fstr.FSTR-D-22-00079

5. Sofian FF, Subarnas A, Hakozaki M, Uesugi S, Koseki T, Shiono Y. Tridysoxyphenols A and B, two new trimeric sesquiterpene phenols from Dysoxylum parasiticum leaves . Phytochem. Lett. 50:134-140, 2022. https://doi.org/10.1016/j.phytol.2022.06.004

6. Uesugi S, Hakozaki M, Kanno Y, Takahashi Y, Shindo K, Kimura K, Yano A. Anti-melanogenic effect of furanoeremophilanes identified from edible wild plants belonging to the genus Cacalia. Biosci. Biotechnol. Biochem. 86:1462-1466, 2022. https://doi.org/10.1093/bbb/zbac124

2021年

1. Uesugi S, Hakozaki M, Kanno Y, Takahashi H, Kudo Y, Kimura K, Yamada H, Yano A. A yeast-based screening system identified bakkenolide B contained in Petasites japonicus as an inhibitor of interleukin-2 production in a human T cell line. Biosci. Biotechnol. Biochem. 85:2153-2160, 2021.  https://doi.org/10.1093/bbb/zbab130【日本農芸化学会 2021年 BBB論文賞 受賞】

2. Sato H, Yano A, Shimoyama Y, Sato T, Sugiyama Y, Kishi M. Associations of streptococci and fungi amounts in the oral cavity with nutritional and oral health status in institutionalized elders: a cross sectional study. BMC Oral Health 21:590, 2021. https://doi.org/10.1186/s12903-021-01926-0

3. 酒井里奈、矢野明 「地域の未利用資源を活用したサステイナブル原料について」FRAGRANCE JOURNAL 49(6):70-73. http://id.ndl.go.jp/bib/031499371

2020年

1. Yoshida J, Okawa Y, Oyama T, Shimoda N, Uesugi S, Takagi H, Ito Y, Kimura K. Inhibition of calcineurin and glycogen synthase kinase-3β by ricinoleic acid derived from castor oil. Lipids 55:89-99, 2020.  https://doi.org/10.1002/lipd.12208

2. Yuki S, Uemura A, Hakozaki M, Yano A, Abe M, Misawa Y, Baba N, Yamada H. Identification of a novel enzyme from E. pacifica that acts as an eicosapentaenoic 8R-LOX and docosahexaenoic 10R-LOX. Sci. Rep. 10:20592, 2020.  https://doi.org/10.1038/s41598-020-77386-3

3. 上杉祥太、木村賢一「微生物二次代謝産物から見出した共有結合性化合物の多様な化学生物学的特徴」生化学 92:556-562, 2020. https://doi.org/10.14952/SEIKAGAKU.2020.920556

2019年

1. Yamada H, Hakozaki M, Shiraishi A, Kumagai K, Ido A, Tsurumi K. Changes in lipids during the ovary maturation process of Balanus rostratus. Zoological science 36(3):182-188, 2019. https://doi.org/10.2108/zs180129

2. 矢野 明、阿部 晶子、岸 光男 「舌の微生物と口腔内状況 第3回:舌背上の真菌」 日本歯科評論 Vol917:161-164, 2019.

3. Uchida T, Koshino H, Abe J, Hakozaki M, Yamada H, Kimura K. Isolation of yeast Ca2+ signal transduction inhibitors from the Early Cretaceous Burmese amber. Fitoterapia 134:422-428, 2019. https://doi.org/10.1016/j.fitote.2019.02.018

4. Shimizu E, Koshino H, Noro A, Maruyama M, Shimoda N, Uesugi S, Ohnishi M, Kimura K. Isolation of a spirolactone norditerpenoid as a yeast Ca2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity. Fitoterapia 134:290-296, 2019. https://doi.org/10.1016/j.fitote.2019.02.027

5. Yamada H, Hakozaki M, Uemura A, Yamashita T. Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells. J. Lipid Res. 60:1491-1502, 2019. https://doi.org/10.1194/jlr.M090712

6. Uesugi S, Honmura Y, Nishiyama M, Kusakabe K, Tonouchi A, Yamashita T, Hashimoto M, Kimura K. Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors. Bioorg. Med. Chem. 27:115161, 2019. https://doi.org/10.1016/j.bmc.2019.115161

7. 矢野明、岸光男「口腔保健用ナマコ加工食品の開発」化学と生物Vol57(12):760-765,2019.  https://doi.org/10.1271/kagakutoseibutsu.57.760

2018年

1. Shiono Y, Furukawa M, Koseki T, Kwon E, Kunrniawan A H, Sato S, Harneti D, Supratman U, Uesugi S,  Kimura K. A pyrrocidine derivative produced by fungus Neonectria ramulariae In-2 isolated from a Beetle Holotrichia picea. Phytochemistry Letter 26:120-124, 2018. https://doi.org/10.1016/j.phytol.2018.05.030

2. Takahashi H, Kikuchi-Fujisaki S, Yoshida C, Yamada H,Yamashita T, Konno N, Takeda T. Gtgen3A, a novel plant GH3 β-glucosidase, modulates gentio-oligosaccharide metabolism. Gentiana. Biochem. J. 475(7):1309-1322,2018. https://doi.org/10.1042/bcj20170866

2017年

1. Yamada H, Yamazaki Y, Koike S, Hakozaki M, Nagahora N, Yuki S, Yano A, Tsurumi K, Okumura T. Lipids,fatty acids and hydroxy-fatty acids of Euphausia pacifica. Scientific Reports 7:9944,2017. https://doi.org/10.1038/s41598-017-09637-9 

2. Nagahora N, Yamada H, Kikuchi S, Hakozaki M, Yano A. Nrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells. Nutrients 9:1001,2017. https://doi.org/10.3390/nu9091001

3. Yano A, Takakusagi M, Oikawa K, Nakajo S, Sugawara T. Xanthophyll levels in foxtail millet grains according to variety and harvesting time. Plant Prod Sci 20(1):136-143, 2017. https://doi.org/10.1080/1343943X.2016.1246347

4. Hosogane M, Bosu L, Fukumoto E, Yamada H, Sato S and Nakayama K. Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells. Genes to Cell 22, 360-375, 2017. https://doi.org/10.1111/gtc.12482

5. 山田秀俊 「イサダからの新規肥満抑制物質 8-HEPE の同定および抽出方法の開発」 JATAFF ジャーナル 5(5), 2017.

2016年

1. Yamada H, Kikuchi S, Hakozaki M, Motodate K, Nagahora N, Hirose M. 8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice. Journal of Lipids,2016:7498508. https://doi.org/10.1155/2016/7498508

2. 山田秀俊 オキアミの機能性 FOOD STYLE21 2016年12月号 (Vol.20,No.12:74-77).

3. 長澤孝志、矢野明、高草木雅人 雑穀の食文化と機能性 Functional Food 2016 Vol.10 No.2:94-99. http://id.ndl.go.jp/bib/027794422

2015年

1. Yano A,  Ito K, Miwa Y, Kanazawa Y, Chiba A, Iigo Y, Kashimoto Y, Kanda A, Murata S, Makino M. The peptide vaccine combines with prior immunization of a conventional diphtheria-tetanus toxoid vaccine induced amyloid beta binding antibodies on cynomolgus monkeys and guinea pigs. J. Immun. Res. 2015:ID786501.  https://doi.org/10.1155/2015/786501

2014年

1. Yamada H, Oshiro E, Kikuchi S,Hakozaki M, Takahashi H, Kimura K. Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs. J. Lipid Res. (2014) 55(5):895-904. https://doi.org/10.1194/jlr.M047514

 2. 山田秀俊 イサダ由来の8-ヒドロキシエイコサペンタエン酸（8-HEPE）による脂肪燃焼促進作用 New Food Industry (2014-09) 56(9):29-34

 3. Yamada H, Kikuchi S, Inui T,Takahashi H, Kimura KI. Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-a, iNOS and Cox-2 mRNA expression and blocks NF-κB promoter activity in murine macrophages. PLoS ONE (2014) 9(11): e113834. https://doi.org/10.1371/journal.pone.0113834

 4. Kurose T, SaitoY, Nakagawa Y, Yano A, ItoK, Kawarasaki Y. Secretory expression of Lentinula edodes intracellular laccase by yeast high-cell-density system: Sub-milligram production of difficult-to-express secretory protein. J Biosci Bioeng (2014) 117(6):659-63. https://doi.org/10.1016/j.jbiosc.2013.11.014

5. 山田秀俊 イサダ（ツノナシオキアミ）由来の新たな抗肥満成分：8-HEPE BIO INDUSTRY (2014) 31(12):46-51

2013年

1. Yano A, Abe A, Aizawa F, Yamada H,Minami K, Matsui M, Kishi M. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Home.  Mar. Drugs (2013) 11:4993-5007.  https://doi.org/10.3390/md11124993

 2. Yano A, Miwa Y, Kanazawa Y, Ito K,Makino M, Imai S, Hanada N, Nisizawa T. A novel method for enhancement of peptide vaccination utilizing T-cell epitopes from conventional vaccines. Vaccine (2013) 31(11):1510-1515. https://doi.org/10.1016/j.vaccine.2012.12.083

3. Nakade K, Nakagawa Y, Yano A, Konno N, Sato T, Sakamoto Y. Effective induction of pblac1 laccase by copper ion in Polyporus brumalis ibrc05015. Fungal. Biol. (2013) 117(1):52-61.  https://doi.org/10.1016/j.funbio.2012.11.005

2012年

1. Sadzuka Y, Sugiyama I,Miyashita M, Ueda T, Kikuchi S, Oshiro E, Yano A, Yamada H. Beneficial effects by intake of Euphausiacea pacifica on high-fat diet-induced obesity. Biol. Pharm. Bull. (2012) 35:568-572. https://doi.org/10.1248/bpb.35.568

2. Yano A, Kikuchi S, TakahashiT, Kohama K, Yoshida Y. Inhibitory effects of the phenolic fraction from the pomace of Vitis coignetiae on biofilm formation by Streptococcus mutans. Arch. Oral Biol. (2012) 57:711-719. https://doi.org/10.1016/j.archoralbio.2012.01.001

3. Yano A, Konno N, Imai S, KatoH. Inhibitory effects of polysaccharides on the cariogenic activities of Streptococcus mutans. Biosci. Biotechnol. Biochem. (2012) 76:2313-2316.  https://doi.org/10.1271/bbb.120464

4. Takahashi H,Yamada H, Yoshida C, Imamura T. Modification of light quality improves the growth and medicinal quality of clonal plantlets derived from the herbal plant Gentiana. Plant Biotechnology (2012) 29(3):315-318.  https://doi.org/10.5511/plantbiotechnology.12.0302a

5. Kimata K, Yamaguchi M, Saito Y, Hata H, Miyake K, Yamane T, Nakagawa Y, Yano A, Ito K, Kawarasaki Y. High cell-density expression system: A novel method for extracellular production of "difficult-to-express" proteins. J. Biosci. Bioeng. (2012) 113(2):154-159. https://doi.org/10.1016/j.jbiosc.2011.10.007

2011年

1. Yamada H, Ueda T, Yano A. Water-Soluble Extract of Pacific Krill Prevents Triglyceride Accumulation in Adipocytes by Suppressing PPARγ and C/EBPα Expression. PLoS ONE. (2011) 6: e21952. https://doi.org/10.1371/journal.pone.0021952

２. Kimata K, Yamaguchi M, Saito Y, HataH, Miyake K, Yamane T, Nakagawa Y, Yano A, Ito K, and Kawarasaki Y. High cell-density expression system: A novel method for extracellular production of "difficult-to-express" proteins. J Biosci Bioeng. (2012) 113(2):154-9. https://doi.org/10.1016/j.jbiosc.2011.10.007

2010年

1. Sasaki-Imamura T, Yano A, Yoshida Y. Production of indol from L-tryptophan and effects of these compounds on biofilm formation by Fusobacterium nucleatum ATCC25586. App. Environ. Microbiol.  (2010) 76:4260-4268.  https://doi.org/10.1128/AEM.00166-10

2. Nakade K, Nakagawa Y, Yano A, Sato T, Sakamoto Y. Characterization of an extracellular laccase, PbLac1, purified from Polyporus brumalis. Fungal Biology  (2010) 114:609-618. https://doi.org/10.1016/j.funbio.2010.05.002

3. Nakagawa Y, Sakamoto Y, Kikuchi S, Sato T, Yano A. A chimeric laccase with hybrid properties of the parental Lentinula edodes laccases. Microbiological Research. (2010) 165:392-401. https://doi.org/10.1016/j.micres.2009.08.006

4. Nakagawa Y, Kikuchi S, Sakamoto Y, Yano A. Identification and characterization of CcCTR1, a copper uptake transporter-like gene, in Coprinopsis cinerea. Microbiological Research. (2010) 165:276-287. https://doi.org/10.1016/j.micres.2009.05.004

5. Yano A, Kikuchi S, YamashitaY, Sakamoto Y, Nakagawa Y, Yoshida Y. The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation. Appl. Microbiol. Biotechnol. (2010) 86(2):615-623. https://doi.org/10.1007/s00253-009-2323-y

2009年

1. Yano A, Kikuchi S, Nakagawa Y,Sakamoto Y, Sato T. Secretory expression of the non-secretory-type Lentinula edodes laccase by Aspergillus 

      oryzae. Microbiolgical Research.(2009) 164:642-649. https://doi.org/10.1016/j.micres.2008.12.001

2008年

1. Sakamoto Y, Keiko N, Yano A, Nakagawa Y, Hirano T, Irie T, Watanabe H, Nagai M, Sato T. Heterologous expression of lcc1 from Lentinula edodes in tobacco BY-2 cells results in the production an active, secreted form of fungal laccase. Appl. Microbiol. Biotechnol. (2008) 79:971-980. https://doi.org/10.1007/s00253-008-1507-1

特許

1. 特許第6977940号 　台湾：発明第I697331号      米国：US 11,272,727 B2
　特許名称：ナマコサポニン含有エキス抽出および定量化方法  “Method for extracting sea cucumber saponin-containing extract and method for maintaining constant content there of”
　発明者：矢野明、岸光男、澤井隆郎、佐々木隆男、小野昭男

2. 特許第6315536号
　特許名称：PPAR活性化剤
　発明者：山田秀俊、菊池明香、木村賢一

3.特許第6604529号
　特許名称：ヒドロキシエイコサペンタエン酸の取得方法
　発明者：山田秀俊、菊池明香、高橋秀行、木村賢一

4. 特許第5998312号
　特許名称：オキアミの水溶性抽出物の薬理用途
　発明者：山田秀俊、上田智広、杉山育美、宮下宙子、菊池明香、佐塚泰之、矢野明

5. 特許第5800457号
　特許名称：高酸化還元電位型ラッカーゼの生産方法
　発明者：中出啓子、中川裕子、坂本裕一、菊地明香、木村亜希子、矢野明

6. 特許第5097695号
　特許名称：抗アミロイドβペプチド抗体生産誘導用のペプチドワクチン
　発明者：矢野 明、三輪尚克、西澤俊樹

出願

1. 特願2020-503591
　特許名称：新規の 8-リポキシゲナーゼおよびその利用
　発明者：山田秀俊、結城彩花、矢野明、馬場忠広、三澤嘉久

2. 特願2018-106553
　特許名称： 8-ヒドロキシエイコサペンタエン酸の薬理用途
　発明者：山田秀俊、弘瀬雅教、衣斐美歩

3. 特願2018-070235
　特許名称：オキアミ成分含有組成物の製造方法
　発明者：山田秀俊、白石朗子、箱崎真友佳、長洞望、矢野明、山崎裕也、小池誠治

4. 特願2014-014973
　特許名称：NFκB転写活性化阻害剤
　発明者：山田秀俊、菊池明香、高橋秀行、木村賢一

5. 特願2008-35207
　特許名称：シイタケラッカーゼ及びそれをコードする核酸及びそれらを用いた基質の酸化方法
　発明者：矢野明、中川裕子、菊地明香、坂本裕一、佐藤利次

6. 特願2008-243568
　特許名称：齲蝕予防のための食品及び口腔ケア剤組成物
　発明者：矢野明、吉田康夫、加藤裕久、菊地明香、坂本裕一、中川裕子